We are using Veeam Enterprise Backup & Replication 12 in a mixed VMware VM and physical Windows network.
We have upgraded all of our Windows servers to Server 2025. Backups on non-domain controllers had no issue post update but our domain controllers are all failing with the same error once the OS was upgraded: Failed to index guest file system. VSSControl: Index failed
There are no connectivity issues between the domain controllers and the Veeam servers and proxies. The domain controllers were not all upgraded on the same day, but each would fail as soon as the OS upgrade occurred. So one day the DC running on Server 2022 would be able to be backed up with no issues, the night its upgraded it would fail. No other changes other than OS upgraded. No changes to virtualization or network infrastructure.

