Hey @Moustafa_Hindawi ...I found a couple posts on the Forums, as well as one on HPE’s site:

https://forums.veeam.com/vmware-vsphere-f24/veeam-and-hpe-simplivity-best-practice-t71745.html
https://forums.veeam.com/vmware-vsphere-f24/veeam-backup-with-hpe-simplivity-best-practice-t59300.html
https://community.hpe.com/t5/hpe-simplivity/hpe-simplivity-veeam-storeonce-best-practice/td-p/7158992

Looks like the main stipulation is to NOT use hotadd with it. Either DirectSAN or nbd. Otherwise, I think not much else.

Hello  @Moustafa_Hindawi,

You can find the simplivity + veeam best practices here : Livre blanc technique : Veeam Backup & Replication sur HPE SimpliVity 380

Use NBD and you will avoid lot of issue :)

nbd is the way with simplivity. Check the link below if you want to increase performance as well.

v11: NBD multi-threading for VMware backup | Veeam Community Resource Hub

Hello @coolsport00 , @BertrandFR @YParis 

Thank you so much for your response and support!

No worries at all @Moustafa_Hindawi 

Hope it helped.

All replies are the best answer, however, I have to choose only one :(